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Extra-mitochondrial mouse frataxin and its implications for mouse models of Friedreich’s ataxia
Mature frataxin is essential for the assembly of iron–sulfur cluster proteins including a number of mitochondrial enzymes. Reduced levels of mature frataxin (81-20) in human subjects caused by the genetic disease Friedreich’s ataxia results in decreased mitochondrial function, neurodegeneration, and...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7519113/ https://ncbi.nlm.nih.gov/pubmed/32978498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72884-w |
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