CpG and non-CpG Presenilin1 methylation pattern in course of neurodevelopment and neurodegeneration is associated with gene expression in human and murine brain

The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase complex, a key enzyme that cleaves the amyloid-β protein precursor (AβPP), to generate the amyloid-β (Aβ) peptides, involved in Alzheimer’s Disease (AD). Other substrates of the γ-secretase, such as E-cadherin and Notch1,...

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Veröffentlicht in:Epigenetics
Hauptverfasser: Monti, Noemi, Cavallaro, Rosaria A., Stoccoro, Andrea, Nicolia, Vincenzina, Scarpa, Sigfrido, Kovacs, Gabor G., Fiorenza, Maria Teresa, Lucarelli, Marco, Aronica, Eleonora, Ferrer, Isidre, Coppedè, Fabio, Troen, Aron M., Fuso, Andrea
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7518704/
https://ncbi.nlm.nih.gov/pubmed/32019393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2020.1722917
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