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Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kp(uu)) on Prediction of Drug-Drug Interactions
PURPOSE: To examine the theoretical/practical utility of the liver-to-blood partition coefficient (Kp(uu)) for predicting drug-drug interactions (DDIs), and compare the Kp(uu)-approach to the extended clearance concept AUC(R)-approach. METHODS: The Kp(uu) relationship was derived from first principl...
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| Vydáno v: | Pharm Res |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7518636/ https://ncbi.nlm.nih.gov/pubmed/32215750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-020-02797-w |
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