Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia

Hyperoxia (HO)-induced lung injury contributes to bronchopulmonary dysplasia (BPD) in preterm newborns. Intractable wheezing seen in BPD survivors is associated with airway remodeling (AWRM). Sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) signaling promotes HO-mediated neonatal BPD; howe...

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Udgivet i:Am J Physiol Lung Cell Mol Physiol
Main Authors: Ha, Alison W., Sudhadevi, Tara, Ebenezer, David L., Fu, Panfeng, Berdyshev, Evgeny V., Ackerman, Steven J., Natarajan, Viswanathan, Harijith, Anantha
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2020
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7518054/
https://ncbi.nlm.nih.gov/pubmed/32697651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00169.2020
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