Clinicopathologic significance of nuclear HER4 and phospho-YAP(S(127)) in human breast cancers and matching brain metastases

BACKGROUND: Human epidermal growth factor receptor-4 (HER4) and yes-associated protein-1 (YAP) are candidate therapeutic targets in oncology. YAP’s transcriptional coactivation function is modulated by the HER4 intracellular domain (HER4-ICD) in vitro, but the clinical relevance of this has not been...

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Detalhes bibliográficos
Publicado no:Ther Adv Med Oncol
Main Authors: Kalita-de Croft, Priyakshi, Lim, Malcolm, Chittoory, Haarika, de Luca, Xavier M., Kutasovic, Jamie R., Day, Bryan W., Al-Ejeh, Fares, Simpson, Peter T., McCart Reed, Amy E., Lakhani, Sunil R., Saunus, Jodi M.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7517995/
https://ncbi.nlm.nih.gov/pubmed/33014146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835920946259
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