Expression of a Human Caveolin-1 Mutation in Mice Drives Inflammatory and Metabolic Defect-Associated Pulmonary Arterial Hypertension

Background: In 2012, mutations in Cav1 were found to be the driving mutation in several cases of heritable pulmonary arterial hypertension (PAH). These mutations replaced the last 21 amino acids of Cav1 with a novel 22-amino-acid sequence. Because previously only Cav1 knockouts had been studied in t...

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Detalhes bibliográficos
Publicado no:Front Med (Lausanne)
Main Authors: Rathinasabapathy, Anandharajan, Copeland, Courtney, Crabtree, Amber, Carrier, Erica J., Moore, Christy, Shay, Sheila, Gladson, Santhi, Austin, Eric D., Kenworthy, Anne K., Loyd, James E., Hemnes, Anna R., West, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516012/
https://ncbi.nlm.nih.gov/pubmed/33015095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2020.00540
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