Clinical translation of (18)F-fluoropivalate – a PET tracer for imaging short-chain fatty acid metabolism: safety, biodistribution, and dosimetry in fed and fasted healthy volunteers

BACKGROUND: Fatty acids derived de novo or taken up from the extracellular space are an essential source of nutrient for cell growth and proliferation. Radiopharmaceuticals including (11)C-acetate, and (18)F-FAC (2-(18)F-fluoroacetate), have previously been used to study short-chain fatty acid (SCFA...

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Detalles Bibliográficos
Publicado en:Eur J Nucl Med Mol Imaging
Main Authors: Dubash, Suraiya R., Keat, Nicholas, Kozlowski, Kasia, Barnes, Chris, Allott, Louis, Brickute, Diana, Hill, Sam, Huiban, Mickael, Barwick, Tara D., Kenny, Laura, Aboagye, Eric O.
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2020
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515955/
https://ncbi.nlm.nih.gov/pubmed/32123971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-020-04724-y
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