Mint3 depletion restricts tumor malignancy of pancreatic cancer cells by decreasing SKP2 expression via HIF-1

Pancreatic cancer is one of the most fatal cancers without druggable molecular targets. Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcriptional factor that promotes malignancy in various cancers including pancreatic cancer. Herein, we found that HIF-1 is accumulated in normoxic or mode...

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Publicat a:Oncogene
Autors principals: Kanamori, Akane, Matsubara, Daisuke, Saitoh, Yurika, Fukui, Yuya, Gotoh, Noriko, Kaneko, Shuichi, Seiki, Motoharu, Murakami, Yoshinori, Inoue, Jun-ichiro, Sakamoto, Takeharu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515798/
https://ncbi.nlm.nih.gov/pubmed/32826949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01423-8
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