Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions

Hippuristanol (Hipp) is a natural product that selectively inhibits protein synthesis by targeting eukaryotic initiation factor (eIF) 4A, a DEAD-box RNA helicase required for ribosome recruitment to mRNA templates. Hipp binds to the carboxyl-terminal domain of eIF4A, locks it in a closed conformatio...

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Pubblicato in:Nucleic Acids Res
Autori principali: Steinberger, Jutta, Shen, Leo, J. Kiniry, Stephen, Naineni, Sai Kiran, Cencic, Regina, Amiri, Mehdi, Aboushawareb, Sarah A E, Chu, Jennifer, Maïga, Rayelle Itoua, Yachnin, Brahm J, Robert, Francis, Sonenberg, Nahum, Baranov, Pavel V, Pelletier, Jerry
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515738/
https://ncbi.nlm.nih.gov/pubmed/32766783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa662
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