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Harnessing the vulnerabilities of p53 mutants in lung cancer – Focusing on the proteasome: a new trick for an old foe?

Gain-of-function (GOF) p53 mutations occur commonly in human cancer and lead to both loss of p53 tumor suppressor function and acquisition of aggressive cancer phenotypes. The oncogenicity of GOF mutant p53 is highly related to its abnormal protein stability relative to wild type p53, and overall st...

詳細記述

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書誌詳細
出版年:Cancer Biol Ther
主要な著者: Oduah, Eziafa I., Grossman, Steven R.
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515531/
https://ncbi.nlm.nih.gov/pubmed/32041464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2019.1702403
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