Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity

Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, while germline heterozygosity for mutant APC produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with a predisposition to colorectal cancer. In these s...

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Detaylı Bibliyografya
Yayımlandı:Cancer Biol Ther
Asıl Yazarlar: Pattison, Amanda M., Barton, Joshua R., Entezari, Ariana A., Zalewski, Alicja, Rappaport, Jeff A., Snook, Adam E., Waldman, Scott A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2020
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515455/
https://ncbi.nlm.nih.gov/pubmed/32594830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2020.1779005
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