The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance

Reverse causality has made it difficult to establish the causal directions between obesity and prediabetes and obesity and insulin resistance. To disentangle whether obesity causally drives prediabetes and insulin resistance already in non-diabetic individuals, we utilized the UK Biobank and METSIM...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Miao, Zong, Alvarez, Marcus, Ko, Arthur, Bhagat, Yash, Rahmani, Elior, Jew, Brandon, Heinonen, Sini, Muñoz-Hernandez, Linda Liliana, Herrera-Hernandez, Miguel, Aguilar-Salinas, Carlos, Tusie-Luna, Teresa, Mohlke, Karen L., Laakso, Markku, Pietiläinen, Kirsi H., Halperin, Eran, Pajukanta, Päivi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515203/
https://ncbi.nlm.nih.gov/pubmed/32925908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009018
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