Accurate estimation of cell composition in bulk expression through robust integration of single-cell information

We present Bisque, a tool for estimating cell type proportions in bulk expression. Bisque implements a regression-based approach that utilizes single-cell RNA-seq (scRNA-seq) or single-nucleus RNA-seq (snRNA-seq) data to generate a reference expression profile and learn gene-specific bulk expression...

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Publicado en:Nat Commun
Autores principales: Jew, Brandon, Alvarez, Marcus, Rahmani, Elior, Miao, Zong, Ko, Arthur, Garske, Kristina M., Sul, Jae Hoon, Pietiläinen, Kirsi H., Pajukanta, Päivi, Halperin, Eran
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181686/
https://ncbi.nlm.nih.gov/pubmed/32332754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15816-6
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