The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance

Reverse causality has made it difficult to establish the causal directions between obesity and prediabetes and obesity and insulin resistance. To disentangle whether obesity causally drives prediabetes and insulin resistance already in non-diabetic individuals, we utilized the UK Biobank and METSIM...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Miao, Zong, Alvarez, Marcus, Ko, Arthur, Bhagat, Yash, Rahmani, Elior, Jew, Brandon, Heinonen, Sini, Muñoz-Hernandez, Linda Liliana, Herrera-Hernandez, Miguel, Aguilar-Salinas, Carlos, Tusie-Luna, Teresa, Mohlke, Karen L., Laakso, Markku, Pietiläinen, Kirsi H., Halperin, Eran, Pajukanta, Päivi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515203/
https://ncbi.nlm.nih.gov/pubmed/32925908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009018
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