The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance

Reverse causality has made it difficult to establish the causal directions between obesity and prediabetes and obesity and insulin resistance. To disentangle whether obesity causally drives prediabetes and insulin resistance already in non-diabetic individuals, we utilized the UK Biobank and METSIM...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Miao, Zong, Alvarez, Marcus, Ko, Arthur, Bhagat, Yash, Rahmani, Elior, Jew, Brandon, Heinonen, Sini, Muñoz-Hernandez, Linda Liliana, Herrera-Hernandez, Miguel, Aguilar-Salinas, Carlos, Tusie-Luna, Teresa, Mohlke, Karen L., Laakso, Markku, Pietiläinen, Kirsi H., Halperin, Eran, Pajukanta, Päivi
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515203/
https://ncbi.nlm.nih.gov/pubmed/32925908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009018
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