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Hsp90 chaperones have an energetic hot‐spot for binding inhibitors
Although Hsp90‐family chaperones have been extensively targeted with ATP‐competitive inhibitors, it is unknown whether high affinity is achieved from a few highly stabilizing contacts or from many weaker contacts within the ATP‐binding pocket. A large‐scale analysis of Hsp90α:inhibitor structures sh...
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| Publicat a: | Protein Sci |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley & Sons, Inc.
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7513732/ https://ncbi.nlm.nih.gov/pubmed/32812680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3933 |
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