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Resolving Hot Spots in the C-Terminal Dimerization Domain that Determine the Stability of the Molecular Chaperone Hsp90

Human heat shock protein of 90 kDa (hHsp90) is a homodimer that has an essential role in facilitating malignant transformation at the molecular level. Inhibiting hHsp90 function is a validated approach for treating different types of tumors. Inhibiting the dimerization of hHsp90 via its C-terminal d...

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書誌詳細
主要な著者: Ciglia, Emanuele, Vergin, Janina, Reimann, Sven, Smits, Sander H. J., Schmitt, Lutz, Groth, Georg, Gohlke, Holger
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997499/
https://ncbi.nlm.nih.gov/pubmed/24760083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096031
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