Synthesis and biological evaluation of S-lipidated lipopeptides of a connexin 43 channel inhibitory peptide

The synthesis and biological activity of 42 novel S-lipidated analogues of a connexin 43 channel inhibitory Peptide5 is described. Unmodified Peptide5 moderates hemichannels and gap junctions that are both implicated in the progression of neurological disease. Peptide5 was site-specifically modified...

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Foilsithe in:RSC Med Chem
Main Authors: Yang, Sung-Hyun, Clemett, Connor A., Brimble, Margaret A., O'Carroll, Simon J., Harris, Paul W. R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Royal Society of Chemistry 2020
Ábhair:
Chemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513673/
https://ncbi.nlm.nih.gov/pubmed/33479696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00172d
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