Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype

BACKGROUND: Chronic glial dysfunction may contribute to the pathogenesis of frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) levels of glia-derived proteins YKL-40 and chitotriosidase are increased in Alzheimer's disease (AD) but have not been explored in detail across the spectrum of F...

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Publicado en:Dement Geriatr Cogn Disord
Autores principales: Woollacott, Ione O.C., Nicholas, Jennifer M., Heller, Carolin, Foiani, Martha S., Moore, Katrina M., Russell, Lucy L., Paterson, Ross W., Keshavan, Ashvini, Schott, Jonathan M., Warren, Jason D., Heslegrave, Amanda, Zetterberg, Henrik, Rohrer, Jonathan D.
Formato: Artigo
Lenguaje:Inglês
Publicado: S. Karger AG 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513620/
https://ncbi.nlm.nih.gov/pubmed/32344399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000506282
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