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Balancing Non-Equilibrium Driving with Nucleotide Selectivity at Kinetic Checkpoints in Polymerase Fidelity Control

High fidelity gene transcription and replication require kinetic discrimination of nucleotide substrate species by RNA and DNA polymerases under chemical non-equilibrium conditions. It is known that sufficiently large free energy driving force is needed for each polymerization or elongation cycle to...

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Vydáno v:Entropy (Basel)
Hlavní autoři: Long, Chunhong, Yu, Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7512825/
https://ncbi.nlm.nih.gov/pubmed/33265397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/e20040306
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