Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model

Pancreatic ductal adenocarcinoma is characterized by a strong immunosuppressive network with a dense infiltration of myeloid cells including myeloid-derived suppressor cells (MDSC). Two distinct populations of MDSC have been defined: polymorphonuclear MDSC (PMN-MDSC) and monocytic MDSC (M-MDSC). Sev...

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Dettagli Bibliografici
Pubblicato in:Cancer Immunol Immunother
Autori principali: Metzger, Philipp, Kirchleitner, Sabrina V., Boehmer, Daniel F. R., Hörth, Christine, Eisele, Angelika, Ormanns, Steffen, Gunzer, Matthias, Lech, Maciej, Lauber, Kirsten, Endres, Stefan, Duewell, Peter, Schnurr, Max, König, Lars M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511276/
https://ncbi.nlm.nih.gov/pubmed/32448983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-020-02605-9
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