T95 nucleophosmin phosphorylation as a novel mediator and marker of regulated cell death in acute kidney injury

The function of site-specific phosphorylation of nucleophosmin (NPM), an essential Bax chaperone, in stress-induced cell death is unknown. We hypothesized that NPM threonine 95 (T95) phosphorylation both signals and promotes cell death. In resting cells, NPM exclusively resides in the nucleus and T9...

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Wang, Zhiyong, Belghasem, Mostafa, Salih, Erdjan, Henderson, Joel, Igwebuike, Chinaemere, Havasi, Andrea, Borkan, Steven C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509286/
https://ncbi.nlm.nih.gov/pubmed/32686519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00230.2020
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