The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication

Posaconazole (PCZ) is a clinically approved drug used predominantly for prophylaxis and salvage therapy of fungal infections. Here, we report its previously undescribed anti-human cytomegalovirus (HCMV) activity. By using antiviral assays, we demonstrated that PCZ, along with other azolic antifungal...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Mercorelli, Beatrice, Luganini, Anna, Celegato, Marta, Palù, Giorgio, Gribaudo, Giorgio, Lepesheva, Galina I., Loregian, Arianna
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7508619/
https://ncbi.nlm.nih.gov/pubmed/32690644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00056-20
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