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Multiplexed photo-activation of mRNA with single-cell resolution
We demonstrate sequential optical activation of two types of mRNAs in the same mammalian cell through the sequential photocleavage of small molecule caging groups (‘photo-cages’) tethered to the 5’ untranslated region (5’-UTR) of an mRNA. Synthetic ‘photo-cages’ were conjugated onto target mRNA usin...
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| Publicado en: | ACS Chem Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7507792/ https://ncbi.nlm.nih.gov/pubmed/32484653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00205 |
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