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Multiplexed photo-activation of mRNA with single-cell resolution

We demonstrate sequential optical activation of two types of mRNAs in the same mammalian cell through the sequential photocleavage of small molecule caging groups (‘photo-cages’) tethered to the 5’ untranslated region (5’-UTR) of an mRNA. Synthetic ‘photo-cages’ were conjugated onto target mRNA usin...

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Udgivet i:ACS Chem Biol
Main Authors: Zhang, Dongyang, Jin, Shuaijiang, Piao, Xijun, Devaraj, Neal K.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507792/
https://ncbi.nlm.nih.gov/pubmed/32484653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00205
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