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Metronomic chemotherapy offsets HIFα induction upon maximum‐tolerated dose in metastatic cancers

Conventional maximum‐tolerated dose (MTD) chemotherapy relies on periodic, massive cancer cell ablation events followed by treatment‐free intermissions, stereotypically resulting in resistance, relapse, and mortality. Furthermore, MTD chemotherapy can promote metastatic dissemination via activation...

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Bibliografske podrobnosti
izdano v:EMBO Mol Med
Main Authors: Schito, Luana, Rey, Sergio, Xu, Ping, Man, Shan, Cruz‐Muñoz, William, Kerbel, Robert S
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507002/
https://ncbi.nlm.nih.gov/pubmed/32686360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201911416
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