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Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy

Chemotherapeutic drugs chronically administered to tumor-bearing mice, using a frequent schedule at doses substantially lower than the maximum tolerated dose (MTD) (i.e., metronomic dosing), can cause sustained and potent antiangiogenic effects by targeting the endothelial cells of newly growing tum...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Bocci, Guido, Francia, Giulio, Man, Shan, Lawler, Jack, Kerbel, Robert S.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240719/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14561896/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2135406100
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