Modification of lipid rafts by extracellular vesicles carrying HIV-1 protein Nef induces redistribution of amyloid precursor protein and Tau, causing neuronal dysfunction

HIV-associated neurocognitive disorders (HANDs) are a frequent outcome of HIV infection. Effective treatment of HIV infection has reduced the rate of progression and severity but not the overall prevalence of HANDs, suggesting ongoing pathological process even when viral replication is suppressed. I...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Ditiatkovski, Michael, Mukhamedova, Nigora, Dragoljevic, Dragana, Hoang, Anh, Low, Hann, Pushkarsky, Tatiana, Fu, Ying, Carmichael, Irena, Hill, Andrew F., Murphy, Andrew J., Bukrinsky, Michael, Sviridov, Dmitri
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7504931/
https://ncbi.nlm.nih.gov/pubmed/32732283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014642
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