Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

The EAG (ether-à-go-go) family of voltage-gated K(+) channels are important regulators of neuronal and cardiac action potential firing (excitability) and have major roles in human diseases such as epilepsy, schizophrenia, cancer, and sudden cardiac death. A defining feature of EAG (Kv10–12) channels...

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Vydáno v:J Biol Chem
Hlavní autoři: Burton, Mark J., Cresser-Brown, Joel, Thomas, Morgan, Portolano, Nicola, Basran, Jaswir, Freeman, Samuel L., Kwon, Hanna, Bottrill, Andrew R., Llansola-Portoles, Manuel J., Pascal, Andrew A., Jukes-Jones, Rebekah, Chernova, Tatyana, Schmid, Ralf, Davies, Noel W., Storey, Nina M., Dorlet, Pierre, Moody, Peter C. E., Mitcheson, John S., Raven, Emma L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7504924/
https://ncbi.nlm.nih.gov/pubmed/32723862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014150
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