Heme binding to human CLOCK affects interactions with the E-box

The circadian clock is an endogenous time-keeping system that is ubiquitous in animals and plants as well as some bacteria. In mammals, the clock regulates the sleep–wake cycle via 2 basic helix–loop–helix PER-ARNT-SIM (bHLH-PAS) domain proteins—CLOCK and BMAL1. There is emerging evidence to suggest...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Freeman, Samuel L., Kwon, Hanna, Portolano, Nicola, Parkin, Gary, Venkatraman Girija, Umakhanth, Basran, Jaswir, Fielding, Alistair J., Fairall, Louise, Svistunenko, Dimitri A., Moody, Peter C. E., Schwabe, John W. R., Kyriacou, Charalambos P., Raven, Emma L.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778266/
https://ncbi.nlm.nih.gov/pubmed/31527239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905216116
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