Heme binding to human CLOCK affects interactions with the E-box

The circadian clock is an endogenous time-keeping system that is ubiquitous in animals and plants as well as some bacteria. In mammals, the clock regulates the sleep–wake cycle via 2 basic helix–loop–helix PER-ARNT-SIM (bHLH-PAS) domain proteins—CLOCK and BMAL1. There is emerging evidence to suggest...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Freeman, Samuel L., Kwon, Hanna, Portolano, Nicola, Parkin, Gary, Venkatraman Girija, Umakhanth, Basran, Jaswir, Fielding, Alistair J., Fairall, Louise, Svistunenko, Dimitri A., Moody, Peter C. E., Schwabe, John W. R., Kyriacou, Charalambos P., Raven, Emma L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2019
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778266/
https://ncbi.nlm.nih.gov/pubmed/31527239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905216116
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