Heme binding to human CLOCK affects interactions with the E-box

The circadian clock is an endogenous time-keeping system that is ubiquitous in animals and plants as well as some bacteria. In mammals, the clock regulates the sleep–wake cycle via 2 basic helix–loop–helix PER-ARNT-SIM (bHLH-PAS) domain proteins—CLOCK and BMAL1. There is emerging evidence to suggest...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Freeman, Samuel L., Kwon, Hanna, Portolano, Nicola, Parkin, Gary, Venkatraman Girija, Umakhanth, Basran, Jaswir, Fielding, Alistair J., Fairall, Louise, Svistunenko, Dimitri A., Moody, Peter C. E., Schwabe, John W. R., Kyriacou, Charalambos P., Raven, Emma L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778266/
https://ncbi.nlm.nih.gov/pubmed/31527239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905216116
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