Heme binding to human CLOCK affects interactions with the E-box

The circadian clock is an endogenous time-keeping system that is ubiquitous in animals and plants as well as some bacteria. In mammals, the clock regulates the sleep–wake cycle via 2 basic helix–loop–helix PER-ARNT-SIM (bHLH-PAS) domain proteins—CLOCK and BMAL1. There is emerging evidence to suggest...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Freeman, Samuel L., Kwon, Hanna, Portolano, Nicola, Parkin, Gary, Venkatraman Girija, Umakhanth, Basran, Jaswir, Fielding, Alistair J., Fairall, Louise, Svistunenko, Dimitri A., Moody, Peter C. E., Schwabe, John W. R., Kyriacou, Charalambos P., Raven, Emma L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2019
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778266/
https://ncbi.nlm.nih.gov/pubmed/31527239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905216116
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