The Ca(2+) channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA

The sperm-specific Ca(2+) channel CatSper (cation channel of sperm) controls the influx of Ca(2+) into the flagellum and, thereby, the swimming behavior of sperm. A hallmark of human CatSper is its polymodal activation by membrane voltage, intracellular pH, and oviductal hormones. Whether CatSper is...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Wang, Tao, Young, Samuel, Krenz, Henrike, Tüttelmann, Frank, Röpke, Albrecht, Krallmann, Claudia, Kliesch, Sabine, Zeng, Xu-Hui, Brenker, Christoph, Strünker, Timo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7504923/
https://ncbi.nlm.nih.gov/pubmed/32703901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013218
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