Modeling UBQLN2-mediated neurodegenerative disease in mice: shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity

The ubiquitin-binding proteasomal shuttle protein UBQLN2 is implicated in common neurodegenerative disorders due to its accumulation in disease-specific aggregates and, when mutated, directly causes familial frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS). Like other proteins linked...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Sharkey, Lisa M., Sandoval-Pistorius, Stephanie S., Moore, Shannon J., Gerson, Julia E., Komlo, Robert, Fischer, Svetlana, Negron-Rios, Keyshla Y., Crowley, Emily V., Padron, Francisco, Patel, Ronak, Murphy, Geoffrey G., Paulson, Henry L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7504910/
https://ncbi.nlm.nih.gov/pubmed/32653673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105016
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge