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Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles

The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo. The present study evaluated the influence of the Phe residues’ stereochemistry on the peptides’ opioid activity. Five stereoisomers we...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Molecules
Egile Nagusiak: Brice-Tutt, Ariana C., Senadheera, Sanjeewa N., Ganno, Michelle L., Eans, Shainnel O., Khaliq, Tanvir, Murray, Thomas F., McLaughlin, Jay P., Aldrich, Jane V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7504817/
https://ncbi.nlm.nih.gov/pubmed/32887303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25173999
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