Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion

Aberrant sialylation is frequently found in pancreatic ductal adenocarcinoma (PDA). α2,3-Sialyltransferases (α2,3-STs) ST3GAL3 and ST3GAL4 are overexpressed in PDA tissues and are responsible for increased biosynthesis of sialyl-Lewis (sLe) antigens, which play an important role in metastasis. This...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Guerrero, Pedro Enrique, Miró, Laura, Wong, Bin S., Massaguer, Anna, Martínez-Bosch, Neus, de Llorens, Rafael, Navarro, Pilar, Konstantopoulos, Konstantinos, Llop, Esther, Peracaula, Rosa
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7503936/
https://ncbi.nlm.nih.gov/pubmed/32872308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21176239
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