Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

Most antibodies display very low brain exposure due to the blood-brain barrier (BBB) preventing their entry into brain parenchyma. Transferrin receptor (TfR) has been used previously to ferry antibodies to the brain by using different formats of bispecific constructs. Tetravalent bispecific tandem i...

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發表在:Mol Ther Methods Clin Dev
Main Authors: Do, Tuan-Minh, Capdevila, Cécile, Pradier, Laurent, Blanchard, Véronique, Lopez-Grancha, Mati, Schussler, Nathalie, Steinmetz, Anke, Beninga, Jochen, Boulay, Denis, Dugay, Philippe, Verdier, Patrick, Aubin, Nadine, Dargazanli, Gihad, Chaves, Catarina, Genet, Elisabeth, Lossouarn, Yves, Loux, Christophe, Michoux, François, Moindrot, Nicolas, Chanut, Franck, Gury, Thierry, Eyquem, Stéphanie, Valente, Delphine, Bergis, Olivier, Rao, Ercole, Lesuisse, Dominique
格式: Artigo
語言:Inglês
出版: American Society of Gene & Cell Therapy 2020
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502788/
https://ncbi.nlm.nih.gov/pubmed/33005703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.08.014
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