Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

Most antibodies display very low brain exposure due to the blood-brain barrier (BBB) preventing their entry into brain parenchyma. Transferrin receptor (TfR) has been used previously to ferry antibodies to the brain by using different formats of bispecific constructs. Tetravalent bispecific tandem i...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:Mol Ther Methods Clin Dev
Główni autorzy: Do, Tuan-Minh, Capdevila, Cécile, Pradier, Laurent, Blanchard, Véronique, Lopez-Grancha, Mati, Schussler, Nathalie, Steinmetz, Anke, Beninga, Jochen, Boulay, Denis, Dugay, Philippe, Verdier, Patrick, Aubin, Nadine, Dargazanli, Gihad, Chaves, Catarina, Genet, Elisabeth, Lossouarn, Yves, Loux, Christophe, Michoux, François, Moindrot, Nicolas, Chanut, Franck, Gury, Thierry, Eyquem, Stéphanie, Valente, Delphine, Bergis, Olivier, Rao, Ercole, Lesuisse, Dominique
Format: Artigo
Język:Inglês
Wydane: American Society of Gene & Cell Therapy 2020
Hasła przedmiotowe:
Original Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502788/
https://ncbi.nlm.nih.gov/pubmed/33005703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.08.014
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