Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life

Tekijä Mackness, Brian C., Jaworski, Julie A., Boudanova, Ekaterina, Park, Anna, Valente, Delphine, Mauriac, Christine, Pasquier, Olivier, Schmidt, Thorsten, Kabiri, Mostafa, Kandira, Abdullah, Radošević, Katarina, Qiu, Huawei
Julkaisussa MAbs (2019)

Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models

Tekijä Valente, Delphine, Mauriac, Christine, Schmidt, Thorsten, Focken, Ingo, Beninga, Jochen, Mackness, Brian, Qiu, Huawei, Vicat, Pascale, Kandira, Abdullah, Radošević, Katarina, Rao, Srini, Darbyshire, John, Kabiri, Mostafa
Julkaisussa MAbs (2020)

Engineered Fc-glycosylation switch to eliminate antibody effector function

Tekijä Zhou, Qun, Jaworski, Julie, Zhou, Yanfeng, Valente, Delphine, Cotton, Joanne, Honey, Denise, Boudanova, Ekaterina, Beninga, Jochen, Rao, Ercole, Wei, Ronnie, Mauriac, Christine, Pan, Clark, Park, Anna, Qiu, Huawei
Julkaisussa MAbs (2020)

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

Tekijä Do, Tuan-Minh, Capdevila, Cécile, Pradier, Laurent, Blanchard, Véronique, Lopez-Grancha, Mati, Schussler, Nathalie, Steinmetz, Anke, Beninga, Jochen, Boulay, Denis, Dugay, Philippe, Verdier, Patrick, Aubin, Nadine, Dargazanli, Gihad, Chaves, Catarina, Genet, Elisabeth, Lossouarn, Yves, Loux, Christophe, Michoux, François, Moindrot, Nicolas, Chanut, Franck, Gury, Thierry, Eyquem, Stéphanie, Valente, Delphine, Bergis, Olivier, Rao, Ercole, Lesuisse, Dominique
Julkaisussa Mol Ther Methods Clin Dev (2020)