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POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks
Interhomolog recombination (IHR) occurs spontaneously in somatic human cells at frequencies that are low but sufficient to ameliorate some genetic diseases caused by heterozygous mutations or autosomal dominant mutations. Here we demonstrate that DNA nicks or double-strand breaks (DSBs) targeted by...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7502765/ https://ncbi.nlm.nih.gov/pubmed/32873648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008073117 |
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