Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways

Cisplatin (CP) is a powerful antineoplastic chemotherapeutic agent with broad-spectrum properties. Acute and cumulative cardiotoxicity are major limiting factors for CP therapy. Various pathogenic pathways have been suggested to CP-induced cardiotoxicity; oxidative damage, ER stress, and programmed...

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Bibliographic Details
Published in:Toxicol Rep
Main Authors: Saleh, Dalia O., Mansour, Dina F., Mostafa, Rasha E.
Format: Artigo
Language:Inglês
Published: Elsevier 2020
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501485/
https://ncbi.nlm.nih.gov/pubmed/32995293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2020.08.026
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