Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways

Cisplatin (CP) is a powerful antineoplastic chemotherapeutic agent with broad-spectrum properties. Acute and cumulative cardiotoxicity are major limiting factors for CP therapy. Various pathogenic pathways have been suggested to CP-induced cardiotoxicity; oxidative damage, ER stress, and programmed...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Dalia O. Saleh, Dina F. Mansour, Rasha E. Mostafa
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2020-01-01
Saila:Toxicology Reports
Gaiak:
Cisplatin
Cardiotoxicity
ER stress
Apoptosis
GRP78
Calpain-1
Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S2214750020303887
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