Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production

Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host for heterologous expression of BGCs, a systemic understanding of how its genet...

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Publicado no:iScience
Main Authors: Sulheim, Snorre, Kumelj, Tjaša, van Dissel, Dino, Salehzadeh-Yazdi, Ali, Du, Chao, van Wezel, Gilles P., Nieselt, Kay, Almaas, Eivind, Wentzel, Alexander, Kerkhoven, Eduard J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501462/
https://ncbi.nlm.nih.gov/pubmed/32942174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101525
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