Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production

Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host for heterologous expression of BGCs, a systemic understanding of how its genet...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:iScience
Päätekijät: Sulheim, Snorre, Kumelj, Tjaša, van Dissel, Dino, Salehzadeh-Yazdi, Ali, Du, Chao, van Wezel, Gilles P., Nieselt, Kay, Almaas, Eivind, Wentzel, Alexander, Kerkhoven, Eduard J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2020
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501462/
https://ncbi.nlm.nih.gov/pubmed/32942174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101525
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