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An IMiD-induced SALL4 degron system for selective degradation of target proteins
Regulating the amount of proteins in living cells is a powerful approach for understanding the functions of the proteins. Immunomodulatory drugs (IMiDs) induce the degradation of neosubstrates by interacting with celebron (CRBN) in the cullin E3 ubiquitin ligase complex (CRL4(CRBN)). Here, we develo...
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| Publicado no: | Commun Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7501283/ https://ncbi.nlm.nih.gov/pubmed/32948804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01240-5 |
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