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An IMiD-induced SALL4 degron system for selective degradation of target proteins
Regulating the amount of proteins in living cells is a powerful approach for understanding the functions of the proteins. Immunomodulatory drugs (IMiDs) induce the degradation of neosubstrates by interacting with celebron (CRBN) in the cullin E3 ubiquitin ligase complex (CRL4(CRBN)). Here, we develo...
Guardat en:
| Publicat a: | Commun Biol |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7501283/ https://ncbi.nlm.nih.gov/pubmed/32948804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01240-5 |
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