An IMiD-induced SALL4 degron system for selective degradation of target proteins

Regulating the amount of proteins in living cells is a powerful approach for understanding the functions of the proteins. Immunomodulatory drugs (IMiDs) induce the degradation of neosubstrates by interacting with celebron (CRBN) in the cullin E3 ubiquitin ligase complex (CRL4(CRBN)). Here, we develo...

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Udgivet i:Commun Biol
Main Authors: Yamanaka, Satoshi, Shoya, Yuki, Matsuoka, Saya, Nishida-Fukuda, Hisayo, Shibata, Norio, Sawasaki, Tatsuya
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501283/
https://ncbi.nlm.nih.gov/pubmed/32948804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01240-5
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