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TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
Centrosomes catalyze microtubule formation for mitotic spindle assembly(1). Centrosomes duplicate once per cell cycle in a process controlled the kinase PLK4(2,3). Following chemical PLK4 inhibition, cell division in the absence of centrosome duplication generates centrosome-less cells that exhibit...
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| Publicat a: | Nature |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7501188/ https://ncbi.nlm.nih.gov/pubmed/32908304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2710-1 |
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