RGS4 promotes allergen- and aspirin-associated airway hyper-responsiveness by inhibiting PGE2 biosynthesis

BACKGROUND: Allergens elicit host production of mediators acting on G-protein coupled receptors (GPCRs) to regulate airway tone. Among these is prostaglandin E2 (PGE2), which, in addition to its role as a bronchodilator, has anti-inflammatory actions. Some patients with asthma develop bronchospasm f...

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Vydáno v:J Allergy Clin Immunol
Hlavní autoři: Wong, Gordon S., Redes, Jamie L., Balenga, Nariman, McCullough, Morgan, Fuentes, Nathalie, Gokhale, Ameya, Koziol-White, Cynthia, Jude, Joseph A., Madigan, Laura A., Chan, Eunice C., Jester, William H., Biardel, Sabrina, Flamand, Nicolas, Panettieri, Reynold A., Druey, Kirk M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501178/
https://ncbi.nlm.nih.gov/pubmed/32199913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.03.004
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