Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models

BACKGROUND: A tetravalent live attenuated dengue vaccine, Dengvaxia, sensitised naïve recipients to severe dengue illness upon a subsequent natural dengue infection and is suspected to be due to antibody-dependent enhancement (ADE). ADE has also been implicated in the severe neurological outcomes of...

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Udgivet i:EBioMedicine
Main Authors: Shukla, Rahul, Beesetti, Hemalatha, Brown, Julia A., Ahuja, Richa, Ramasamy, Viswanathan, Shanmugam, Rajgokul K., Poddar, Ankur, Batra, Gaurav, Krammer, Florian, Lim, Jean K., Kale, Sachin, Lal, Altaf A., Swaminathan, Sathyamangalam, Khanna, Navin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501058/
https://ncbi.nlm.nih.gov/pubmed/32949997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102991
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