Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Díaz-Alonso, Javier, Morishita, Wade, Incontro, Salvatore, Simms, Jeffrey, Holtzman, Julia, Gill, Michael, Mucke, Lennart, Malenka, Robert C, Nicoll, Roger A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500950/
https://ncbi.nlm.nih.gov/pubmed/32831170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58042
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