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Revisiting the PD-1 pathway
Programmed Death-1 (PD-1; CD279) is an inhibitory receptor induced in activated T cells. PD-1 engagement by its ligands, PD-L1 and PD-L2, maintains peripheral tolerance but also compromises anti-tumor immunity. Blocking antibodies against PD-1 or its ligands have revolutionized cancer immunotherapy....
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| Udgivet i: | Sci Adv |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Association for the Advancement of Science
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7500922/ https://ncbi.nlm.nih.gov/pubmed/32948597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd2712 |
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