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PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A

The programmed cell death-1 (PD)-1 receptor (CD279) is a potent T cell inhibitor with a critical role in peripheral tolerance, but it can also compromise anti-viral and antitumor T cell responses. The effects of PD-1 on the cell cycle leading to inhibition of T cell expansion are poorly understood....

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Bibliografske podrobnosti
Main Authors: Patsoukis, Nikolaos, Sari, Duygu, Boussiotis, Vassiliki A.
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552912/
https://ncbi.nlm.nih.gov/pubmed/23032366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22135
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